CBX5 (gene)

Chromobox homolog 5

Rendering based on PDB 3FDT.

Available structures
PDB	3FDT, 3I3C

Identifiers

Symbols

CBX5; HP1; HP1A

External IDs

OMIM: 604478 MGI: 109372 HomoloGene: 7257 GeneCards: CBX5 Gene

Gene Ontology
Molecular function	• chromatin binding • protein binding • enzyme binding • protein binding, bridging • methylated histone residue binding • histone deacetylase binding • repressing transcription factor binding
Cellular component	• histone deacetylase complex • kinetochore • nucleus • nuclear envelope • nucleoplasm • chromosome • nuclear heterochromatin • nucleolus • cytoplasm • chromocenter • PML body • transcriptional repressor complex • nuclear centromeric heterochromatin • histone methyltransferase complex
Biological process	• blood coagulation • interspecies interaction between organisms • negative regulation of transcription, DNA-dependent • negative regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
54.62 – 54.67 Mb

Chr 15:
103.02 – 103.07 Mb

PubMed search

[1]

[2]

Chromobox protein homolog 5 is a protein that in humans is encoded by the CBX5 gene.^[1]^[2]

Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, where it mediates gene silencing.[supplied by OMIM]^[2]

1 Interactions
2 See also
3 References
4 Further reading
5 External links

Interactions

CBX5 (gene) has been shown to interact with HDAC9,^[3] Ku70,^[4] MIS12,^[5] Lamin B receptor,^[1] MBD1,^[6]^[7] TAF4,^[8] Histone deacetylase 5,^[3] TRIM28,^[9]^[10]^[11]^[12] HDAC4,^[3] CBX3,^[11] SMARCA4,^[9] DNMT3B,^[13] CHAF1A,^[7]^[12] CBX1^[11] and SUV39H1.^[6]^[14]^[3]

References

^ ^a ^b Ye Q, Worman HJ (Aug 1996). "Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1". J Biol Chem 271 (25): 14653–6. doi:10.1074/jbc.271.25.14653. PMID 8663349.
^ ^a ^b "Entrez Gene: CBX5 chromobox homolog 5 (HP1 alpha homolog, Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23468.
^ ^a ^b ^c ^d Zhang, Chun Li; McKinsey Timothy A, Olson Eric N (Oct. 2002). "Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation". Mol. Cell. Biol. (United States) 22 (20): 7302–12. doi:10.1128/MCB.22.20.7302-7312.2002. ISSN 0270-7306. PMC 139799. PMID 12242305. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139799.
^ Song, K; Jung Y, Jung D, Lee I (Mar. 2001). "Human Ku70 interacts with heterochromatin protein 1alpha". J. Biol. Chem. (United States) 276 (11): 8321–7. doi:10.1074/jbc.M008779200. ISSN 0021-9258. PMID 11112778.
^ Obuse, Chikashi; Iwasaki Osamu, Kiyomitsu Tomomi, Goshima Gohta, Toyoda Yusuke, Yanagida Mitsuhiro (Nov. 2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1". Nat. Cell Biol. (England) 6 (11): 1135–41. doi:10.1038/ncb1187. ISSN 1465-7392. PMID 15502821.
^ ^a ^b Fujita, Naoyuki; Watanabe Sugiko, Ichimura Takaya, Tsuruzoe Shu, Shinkai Yoichi, Tachibana Makoto, Chiba Tsutomu, Nakao Mitsuyoshi (Jun. 2003). "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression". J. Biol. Chem. (United States) 278 (26): 24132–8. doi:10.1074/jbc.M302283200. ISSN 0021-9258. PMID 12711603.
^ ^a ^b Reese, Brian E; Bachman Kurtis E, Baylin Stephen B, Rountree Michael R (May. 2003). "The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1". Mol. Cell. Biol. (United States) 23 (9): 3226–36. doi:10.1128/MCB.23.9.3226-3236.2003. ISSN 0270-7306. PMC 153189. PMID 12697822. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=153189.
^ Vassallo, Milo F; Tanese Naoko (Apr. 2002). "Isoform-specific interaction of HP1 with human TAFII130". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (9): 5919–24. doi:10.1073/pnas.092025499. ISSN 0027-8424. PMC 122877. PMID 11959914. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122877.
^ ^a ^b Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (Nov. 2002). "Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha". EMBO J. (England) 21 (21): 5797–806. doi:10.1093/emboj/cdf560. ISSN 0261-4189. PMC 131057. PMID 12411497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=131057.
^ Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (Sep. 2002). "Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction". J. Cell. Sci. (England) 115 (Pt 17): 3439–48. ISSN 0021-9533. PMID 12154074.
^ ^a ^b ^c Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (Apr. 2001). "Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins". Mol. Cell (United States) 7 (4): 729–39. doi:10.1016/S1097-2765(01)00218-0. ISSN 1097-2765. PMID 11336697.
^ ^a ^b Lechner, M S; Begg G E, Speicher D W, Rauscher F J (Sep. 2000). "Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential". Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449–65. doi:10.1128/MCB.20.17.6449-6465.2000. ISSN 0270-7306. PMC 86120. PMID 10938122. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=86120.
^ Lehnertz, Bernhard; Ueda Yoshihide, Derijck Alwin A H A, Braunschweig Ulrich, Perez-Burgos Laura, Kubicek Stefan, Chen Taiping, Li En, Jenuwein Thomas, Peters Antoine H F M (Jul. 2003). "Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin". Curr. Biol. (England) 13 (14): 1192–200. doi:10.1016/S0960-9822(03)00432-9. ISSN 0960-9822. PMID 12867029.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

MeSH CBX5+protein,+human

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Transcription factors and intracellular receptors

(1) Basic domains

(1.1) Basic leucine zipper (bZIP)	Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) · AP-1 (c-Fos, FOSB, FOSL1, FOSL2, JDP2, c-Jun, JUNB, JUND) · BACH (1, 2) · BATF · BLZF1 · C/EBP (α, β, γ, δ, ε, ζ) · CREB (1, 3, L1) · CREM · DBP · DDIT3 · GABPA · HLF · MAF (B, F, G, K) · NFE (2, L1, L2, L3) · NFIL3 · NRL · NRF (1, 2, 3) · XBP1

(1.2) Basic helix-loop-helix (bHLH)	ATOH1 · AhR · AHRR · ARNT · ASCL1 · BHLHB2 · BMAL (ARNTL, ARNTL2) · CLOCK · EPAS1 · FIGLA · HAND (1, 2) · HES (5, 6) · HEY (1, 2, L) · HES1 · HIF (1A, 3A) · ID (1, 2, 3, 4) · LYL1 · MESP2 · MXD4 · MYCL1 · MYCN · Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) · Neurogenins (1, 2, 3) · NeuroD (1, 2) · NPAS (1, 2, 3) · OLIG (1, 2) · Pho4 · Scleraxis · SIM (1, 2) · TAL (1, 2) · Twist · USF1

(1.3) bHLH-ZIP	AP-4 · MAX · MITF · MNT · MLX · MXI1 · Myc · SREBP (1, 2)

(1.4) NF-1	NFI (A, B, C, X) · SMAD (R-SMAD (1, 2, 3, 5, 9) - I-SMAD (6, 7) - 4)

(1.5) RF-X	RFX (1, 2, 3, 4, 5, ANK)

(1.6) Basic helix-span-helix (bHSH)	AP-2 (α, β, γ, δ, ε)

(2) Zinc finger DNA-binding domains

(2.1) Nuclear receptor (Cys₄)	subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) subfamily 3 (Steroid hormone (Androgen, Estrogen (α, β), Glucocorticoid, Mineralocorticoid, Progesterone), Estrogen related (α, β, γ)) subfamily 4 NUR (NGFIB, NOR1, NURR1) · subfamily 5 (LRH-1, SF1) · subfamily 6 (GCNF) · subfamily 0 (DAX1, SHP)

(2.2) Other Cys₄	GATA (1, 2, 3, 4, 5, 6) · MTA (1, 2, 3) · TRPS1

(2.3) Cys₂His₂	General transcription factors (TFIIA, TFIIB, TFIID, TFIIE (1, 2), TFIIF (1, 2), TFIIH (1, 2, 4, 2I, 3A, 3C1, 3C2)) ATBF1 · BCL (6, 11A, 11B) · CTCF · E4F1 · EGR (1, 2, 3, 4) · ERV3 · GFI1 · GLI-Krüppel family (1, 2, 3, REST, S2, YY1) · HIC (1, 2) · HIVEP (1, 2, 3) · IKZF (1, 2, 3) · ILF (2, 3) · KLF (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17) · MTF1 · MYT1 · OSR1 · PRDM9 · SALL (1, 2, 3, 4) · SP (1, 2, 4, 7, 8) · TSHZ3 · WT1 · Zbtb7 (7A, 7B) · ZBTB (16, 17, 20, 32, 33, 40) · zinc finger (3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 300, 318, 330, 346, 350, 365, 366, 384, 423, 451, 452, 471, 593, 638, 644, 649, 655)

(2.4) Cys₆	HIVEP1

(2.5) Alternating composition	AIRE · DIDO1 · GRLF1 · ING (1, 2, 4) · JARID (1A, 1B, 1C, 1D, 2) · JMJD1B

(3) Helix-turn-helix domains

(3.1) Homeodomain	ARX · CDX (1, 2) · CRX · CUTL1 · DBX (1, 2) · DLX (3, 4, 5) · EMX2 · EN (1, 2) · FHL (1, 2, 3) · HESX1 · HHEX · HLX · Homeobox (A1, A2, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C12, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) · HOPX · IRX (1, 2, 3, 4, 5, 6, MKX) · LMX (1A, 1B) · MEIS (1, 2) · MEOX2 · MNX1 · MSX (1, 2) · NANOG · NKX (2-1, 2-2, 2-3, 2-5, 3-1, 3-2, 6-1, 6-2) · NOBOX · PBX (1, 2, 3) · PHF (1, 3, 6, 8, 10, 16, 17, 20, 21A) · PHOX (2A, 2B) · PITX (1, 2, 3) · POU domain (PIT-1, BRN-3: A, B, C, Octamer transcription factor: 1, 2, 3/4, 6, 7, 11) · OTX (1, 2) · PDX1 · SATB2 · SHOX2 · VAX1 · ZEB (1, 2)

(3.2) Paired box	PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)

(3.3) Fork head / winged helix	E2F (1, 2, 3, 4, 5) · FOX proteins (A1, A2, A3, C1, C2, D3, D4, E1, E3, F1, G1, H1, I1, J1, J2, K1, K2, L2, M1, N1, N3, O1, O3, O4, P1, P2, P3, P4)

(3.4) Heat Shock Factors	HSF (1, 2, 4)

(3.5) Tryptophan clusters	ELF (2, 4, 5) · EGF · ELK (1, 3, 4) · ERF · ETS (1, 2, ERG, SPIB) · ETV (1, 4, 5, 6) · FLI1 · Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) · MYB · MYBL2

(3.6) TEA domain	transcriptional enhancer factor (1, 2, 3, 4)

(4) β-Scaffold factors with minor groove contacts

(4.1) Rel homology region	NF-κB (NFKB1, NFKB2, REL, RELA, RELB) · NFAT (C1, C2, C3, C4, 5)

(4.2) STAT	STAT (1, 2, 3, 4, 5, 6)

(4.3) p53	p53 · TBX (1, 2, 3, 5, 19, 21, 22, Brachyury, TBR1, TBR2) · TP63

(4.4) MADS box	Mef2 (A, B, C, D) · SRF

(4.6) TATA binding proteins	TBP · TBPL1

(4.7) High-mobility group	BBX · HMGB (1, 2, 3, 4) · HMGN (1, 2, 3, 4) · HNF (1A, 1B) · LEF1 · SOX (1, 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 18, 21) · SRY · SSRP1 · TCF (3, 4) · TOX (1, 2, 3, 4)

(4.10) Cold-shock domain	CSDA, YBX1

(4.11) Runt	CBF (CBFA2T2, CBFA2T3, RUNX1, RUNX2, RUNX3, RUNX1T1)

(0) Other transcription factors

(0.2) HMGI(Y)	HMGA (1, 2) · HBP1

(0.3) Pocket domain	Rb · RBL1 · RBL2

(0.5) AP-2/EREBP-related factors	Apetala 2 · EREBP · B3

(0.6) Miscellaneous	ARID (1A, 1B, 2, 3A, 3B, 4A) · CAP · IFI (16, 35) · MLL (2, 3, T1) · MNDA · NFY (A, B, C) · Rho/Sigma

see also transcription factor/coregulator deficiencies
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

CBX5 (gene)

Contents

Interactions

See also

References

Further reading

External links